Multisite error in nginx error log


I use multisite install with 2 subfolder sites, and wp 5.03

In the nginx error log shows lots of errors, to static assets, like the following:

2019/02/14 06:25:28 [error] 8484#8484: *253339 open() “/xxx/xxx/xxxx/public_html/subsite3/wp-content/uploads/sites/3/xxxx/xx/file.jpg” failed (2: No such file or directory), client:, server:, request: “GET /subsite3/wp-content/uploads/sites/3/xxxx/xx/file.jpg HTTP/2.0”, host: “

Obviously subsite3 as a directory folder doesn´t exist.

Is this due to a server misconfiguration?
Is this affecting the performance of the site?
Someone is experiencing the same situation?